Savchenko Iu N
Biull Eksp Biol Med. 1982 Apr;93(4):34-5.
The activity of 2',3'-cyclonucleotide-3-phosphohydrolase (CNP) and leucine aminopeptidase (LAP) was studied for the first time in the blood of patients with diseases of the peripheral nervous system. A spectrophotometric method for CNP activity detection was described. The activity absent from the blood of normal subjects was detectable with statistical significance in the patients with the diseases in question. Analogous results were obtained in the animals with an experimental injury to the myelin coat of the peripheral nerves. Study into the activity of LAP in the pathological conditions under consideration revealed no significant deviations. It is emphasized that CNP may transfer to the blood serum from myelin decay foci and that the method described may be used for diagnostic purposes.
首次对外周神经系统疾病患者血液中的2',3'-环核苷酸-3-磷酸水解酶（CNP）和亮氨酸氨肽酶（LAP）活性进行了研究。描述了一种用于检测CNP活性的分光光度法。在正常受试者血液中不存在的活性，在所讨论疾病的患者中可检测到，具有统计学意义。在外周神经髓鞘实验性损伤的动物中也获得了类似结果。对所考虑病理状况下LAP活性的研究未发现明显偏差。强调CNP可能从髓鞘衰变灶转移至血清，且所描述的方法可用于诊断目的。
