Hayata Y, Kato H, Konaka C, Ono J, Matsushima Y, Yoneyama K, Nishimiya K
Chest. 1982 Jul;82(1):10-4. doi: 10.1378/chest.82.1.10.
Hematoporphyrin derivative (HpD) administration and laser photoradiation were combined to clarify the system's clinical applicability in localizing lung cancer tumors. It was used in 16 cases of lung cancer and in one case of severely atypical squamous metaplasia. Tumors were irradiated 48 hours after intravenous injection of 2.0 to 4.0 mg/kg HpD and fluorescence observed. Fluorescence was seen in 13 lung cancer cases in the case of squamous metaplasia, but results were negative in three of the cases of lung cancer. Among the positive cases was one of occult cancer and two invading the trachea, difficult to recognize by conventional fiberoptic bronchoscopy, as was the severely atypical squamous metaplasia. In the three lung cancer cases not fluorescing, the tumors were obscured by blood, necrotic tissue, or normal mucosa. The method holds promise in the diagnosis of malignant tumors. Nevertheless, it needs further refinement and more studies to elucidate definitive differentiation between malignant and severely atypical, nonmalignant tissue.
将血卟啉衍生物（HpD）给药与激光光辐射相结合，以阐明该系统在定位肺癌肿瘤方面的临床适用性。它被用于16例肺癌患者和1例重度非典型鳞状化生患者。在静脉注射2.0至4.0mg/kg HpD后48小时对肿瘤进行照射，并观察荧光。在鳞状化生的13例肺癌病例中观察到荧光，但3例肺癌病例结果为阴性。在阳性病例中，有1例隐匿性癌和2例侵犯气管的病例，通过传统纤维支气管镜难以识别，重度非典型鳞状化生病例也是如此。在3例未产生荧光的肺癌病例中，肿瘤被血液、坏死组织或正常黏膜遮挡。该方法在恶性肿瘤诊断方面具有前景。然而，它需要进一步完善以及更多研究来阐明恶性组织与重度非典型非恶性组织之间的明确区分。
