Yao L F, MacLeod K M, McNeill J H
Eur J Pharmacol. 1982 Apr 8;79(1-2):147-50. doi: 10.1016/0014-2999(82)90588-x.
Desensitization of guinea pig left atria to the inotropic effects of glucagon was produced in vitro by treatment of the atria with 10(-6) M glucagon for 2 or 15 min. Desensitization of the contractile response was associated with a loss of the ability of glucagon to elevate cyclic AMP levels. A highly significant correlation was found between the increase in contractile force and the increase in cyclic AMP levels in control and glucagon desensitized left atria.
通过用10⁻⁶ M胰高血糖素处理豚鼠离体左心房2分钟或15分钟，可在体外诱导其对胰高血糖素的变力作用产生脱敏。收缩反应的脱敏与胰高血糖素升高环磷酸腺苷（cAMP）水平的能力丧失有关。在对照和经胰高血糖素脱敏的左心房中，发现收缩力增加与环磷酸腺苷水平增加之间存在高度显著的相关性。
