Kastrukoff L, Hamada T, Schumacher U, Long C, Doherty P C, Koprowski H
J Neuroimmunol. 1982 Jun;2(3-4):295-305. doi: 10.1016/0165-5728(82)90062-5.
Virus may be recovered from various areas of the central nervous system (CNS) of mice for as long as 11 days after inoculation of herpes simplex virus type 1 (HSV-1) into the lip. The probability of isolation from any particular region of the CNS seems to be a function of the distance of that area from the root-entry zone of the trigeminal nerve. It is also mouse strain-dependent, with much more extensive evidence of brain infection being found in BALB/c and C3H rather than C57BL/6 mice, in which it is limited to the pons. The virus could not be isolated from the CNS of BALB/c mice after 10 days, though HSV-1 is readily recovered from the trigeminal ganglia at least through day 38. Significant concentrations of HSV-1-specific immunoglobulin (Ig) were demonstrated consistently in cerebrospinal fluid (CSF) from day 12 after exposure to virus. The persistence of relatively high concentrations of IgM in the CSF indicates that much of this antibody may be synthesized locally in the brain.
将1型单纯疱疹病毒（HSV-1）接种到小鼠唇部后，长达11天的时间里都可能从小鼠中枢神经系统（CNS）的各个区域分离出病毒。从CNS任何特定区域分离出病毒的概率似乎取决于该区域与三叉神经根部进入区的距离。这也取决于小鼠品系，在BALB/c和C3H小鼠中发现的脑感染证据比C57BL/6小鼠广泛得多，在C57BL/6小鼠中感染仅限于脑桥。10天后无法从BALB/c小鼠的CNS中分离出病毒，不过至少在第38天之前都能轻易从三叉神经节中分离出HSV-1。从接触病毒后的第12天起，脑脊液（CSF）中持续显示出高浓度的HSV-1特异性免疫球蛋白（Ig）。CSF中相对高浓度IgM的持续存在表明，这种抗体的大部分可能是在脑内局部合成的。
