Levine G, Sartiano G P, Boggs S S, Fried A, Gumerman L W
J Nucl Med. 1976 Dec;17(12):1083-7.
Dimercaprol (BAL) administered 1 hr before 111In-bleomycin in the normal BALB/c mouse produced an early preferential hepatic loading of 111In-bleomycin without a loading of the spleen, skin, bone, or muscle. Liver-to-muscle ratios were increased about threefold under the influence of BAL. Liver (c BAL)/liver (s BAL) ratios also increased threefold at 3 hr whereas relative muscle uptake remained at about unity. Indium-111 chloride (colloid, pH 6.5) used as a control did not show a similar increase. The findings suggest that the kinetics and distribution of 111In-bleomycin in the normal BALB/c mouse can be influenced by pretreatment with BAL.
在正常BALB/c小鼠中，在注射铟-111博来霉素前1小时给予二巯丙醇（BAL），可使铟-111博来霉素早期优先在肝脏蓄积，而脾脏、皮肤、骨骼或肌肉无蓄积。在BAL的影响下，肝脏与肌肉的比值增加了约三倍。在3小时时，肝脏（注射BAL）/肝脏（未注射BAL）的比值也增加了三倍，而相对肌肉摄取量保持在约1。用作对照的氯化铟-111（胶体，pH 6.5）未显示出类似的增加。这些发现表明，BAL预处理可影响铟-111博来霉素在正常BALB/c小鼠中的动力学和分布。
