人EJ膀胱癌细胞癌基因是哈维肉瘤病毒ras基因的同源物。
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.
作者信息
Parada L F, Tabin C J, Shih C, Weinberg R A
出版信息
Nature. 1982 Jun 10;297(5866):474-8. doi: 10.1038/297474a0.
DOI:10.1038/297474a0
PMID:6283357
Abstract
Examination of homologies between retroviral oncogenes and transforming sequences defined by transfection reveals that the human bladder carcinoma (EJ) oncogene is homologous to the Harvey sarcoma virus oncogene (ras). Structural analysis limits the region of homology to a 3.0-kilobase SacI fragment of the EJ oncogene. Both EJ and ras DNA probes detect similar transcripts in transfectants derived from bladder carcinoma cell lines.
摘要
对逆转录病毒癌基因与通过转染定义的转化序列之间的同源性进行检测发现，人膀胱癌（EJ）癌基因与哈维肉瘤病毒癌基因（ras）同源。结构分析将同源区域限定在EJ癌基因的一个3.0千碱基的SacI片段。EJ和ras DNA探针在源自膀胱癌细胞系的转染子中检测到相似的转录本。
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