与哈维鼠肉瘤病毒癌基因同源的正常人基因诱导的哺乳动物细胞致瘤转化。
Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus.
作者信息
Chang E H, Furth M E, Scolnick E M, Lowy D R
出版信息
Nature. 1982 Jun 10;297(5866):479-83. doi: 10.1038/297479a0.
DOI:10.1038/297479a0
PMID:6283358
Abstract
A normal human gene homologous to the p21 ras oncogene of Harvey murine sarcoma virus induced oncogenic transformation and high p21 ras levels in murine fibroblasts when this gene was ligated to a control element (the long terminal repeat) from a murine or feline retrovirus. These results indicate that high levels of a gene product encoded by a normal human oncogene can induce tumorigenic transformation.
摘要
一种与哈维鼠肉瘤病毒的p21 ras癌基因同源的正常人类基因，当该基因与来自鼠类或猫类逆转录病毒的一个控制元件（长末端重复序列）连接时，可诱导鼠成纤维细胞发生致癌转化并使p21 ras水平升高。这些结果表明，由正常人类癌基因编码的高水平基因产物可诱导致瘤性转化。
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