Amara S G, Jonas V, Rosenfeld M G, Ong E S, Evans R M
Nature. 1982 Jul 15;298(5871):240-4. doi: 10.1038/298240a0.
Alternative processing of RNA transcripts from the calcitonin gene results in the production of distinct mRNAs encoding the hormone calcitonin or a predicted product referred to as calcitonin gene-related peptide (CGRP). The calcitonin mRNA predominates in the thyroid while the CGRP-specific mRNA appears to predominate in the hypothalamus. These observations lead us to propose a model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression.
降钙素基因的RNA转录本经过可变加工，产生了编码激素降钙素或一种被称为降钙素基因相关肽（CGRP）的预测产物的不同mRNA。降钙素mRNA在甲状腺中占主导地位，而CGRP特异性mRNA似乎在下丘脑中占主导地位。这些观察结果使我们提出一个模型，其中RNA加工的发育调控被用于增加神经内分泌基因表达的多样性。
