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关于重复刺激期间终板电流时间进程的变化

On the changes of the time course of the end-plate current during repetitive stimulation.

作者信息

Ruzzier F, Di Gregorio F, Scuka M

出版信息

Pflugers Arch. 1982 Mar;393(1):121-2. doi: 10.1007/BF00582404.

DOI:10.1007/BF00582404
PMID:6283466
Abstract

In a previous study it was observed that prolonged repetitive stimulation (10.s-1) markedly lengthened the time course of the end-plate current. In order to investigate whether this effect could be due to a more dispersed release of the mediator or to a decreased clearance of the mediator from the synaptic cleft, the rise time of the end-plate current and of the miniature end-plate current were analyzed. The results show that presynaptic factors may be involved.

摘要

在先前的一项研究中观察到,长时间重复刺激(10次/秒)显著延长了终板电流的时程。为了研究这种效应是由于递质释放更加分散还是由于递质从突触间隙清除减少所致,对终板电流和微小终板电流的上升时间进行了分析。结果表明,可能涉及突触前因素。

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本文引用的文献

1
Intracellular transport in neurons.神经元中的细胞内运输。
Physiol Rev. 1980 Oct;60(4):1167-283. doi: 10.1152/physrev.1980.60.4.1167.
2
Enlarged synaptic vesicles in optic nerve terminals induced by intraocular injection of colchicine.眼内注射秋水仙碱诱导视神经终末突触小泡增大。
Brain Res. 1972 Apr 28;39(2):285-96. doi: 10.1016/0006-8993(72)90437-4.
3
Effect of repetitive stimulation on the frog neuromuscular transmission.重复刺激对青蛙神经肌肉传递的影响。
Pflugers Arch. 1979 Nov;382(2):127-32. doi: 10.1007/BF00584213.
4
A correlation between the effects of anti-mitotic drugs on microtubule assembly in vitro and the inhibition of axonal transport in noradrenergic neurones.抗有丝分裂药物在体外对微管装配的影响与去甲肾上腺素能神经元轴突运输抑制之间的相关性。
J Physiol. 1975 Oct;252(1):283-94. doi: 10.1113/jphysiol.1975.sp011144.
5
Synaptic vesicles and microtubules in frog motor endplates.青蛙运动终板中的突触小泡和微管。
Proc R Soc Lond B Biol Sci. 1978 Dec 18;203(1152):219-27. doi: 10.1098/rspb.1978.0102.