小脑皮质变性伴卵巢癌

Steven M M, Mackay I R, Carnegie P R, Bhathal P S, Anderson R M

Postgrad Med J. 1982 Jan;58(675):47-51. doi: 10.1136/pgmj.58.675.47.

A case is described of progressive cerebellar degeneration in association with ovarian carcinoma, with nearly 4 years elapsing between the onset of neurological illness and the discovery of the carcinoma. Neither treatment with prednisolone nor surgical removal of the tumour effected any improvement, CAT scanning late in the illness showed marked cerebellar atrophy. Histology at post-mortem showed complete loss of cerebellar Purkinje cells. The cerebrospinal fluid gave weak binding to multiple neural components in a solid-phase radio-immuno-assay.

本文描述了一例与卵巢癌相关的进行性小脑变性病例，神经系统疾病发作与癌症发现之间间隔了近4年。泼尼松龙治疗和肿瘤手术切除均未带来任何改善，疾病后期的计算机断层扫描（CAT）显示小脑明显萎缩。尸检组织学检查显示小脑浦肯野细胞完全丧失。脑脊液在固相放射免疫测定中与多种神经成分呈弱阳性结合。