McLellan R, Currie J L, Royal W, Rosenshein N B
Division of Gynecologic Oncology, Department of Neurology, The Johns Hopkins Hospital, Baltimore, Maryland.
Obstet Gynecol. 1988 Dec;72(6):922-5. doi: 10.1097/00006250-198812000-00023.
A case of paraneoplastic cerebellar degeneration complicating ovarian cancer is presented. This rare disorder is characterized by vertigo, nystagmus, diplopia, and ataxia. Neurologic sequelae are progressive, ultimately culminating in complete incapacitation and death. Symptoms of paraneoplastic cerebellar degeneration precede the diagnosis of malignancy in the majority of cases. Marked elevation in the anti-Purkinje cell antibody titer together with immunofluorescent staining techniques suggest that an autoimmune mechanism plays a role in the etiology of this disorder.
本文报告一例并发卵巢癌的副肿瘤性小脑变性病例。这种罕见疾病的特征为眩晕、眼球震颤、复视和共济失调。神经系统后遗症呈进行性发展，最终导致完全失能和死亡。在大多数病例中，副肿瘤性小脑变性的症状先于恶性肿瘤的诊断出现。抗浦肯野细胞抗体滴度显著升高以及免疫荧光染色技术表明，自身免疫机制在该疾病的病因中起作用。
