Cohen F S, Akabas M H, Finkelstein A
Science. 1982 Jul 30;217(4558):458-60. doi: 10.1126/science.6283637.
Fusion of phospholipid vesicles with planar bilayer membranes occurs if the vesicles that contact the planar membrane swell osmotically after the replacement in their medium of an impermeant solute by a permeant one. This finding directly demonstrates that osmotic swelling is a driving force for vesicle-planar membrane fusion. The method used to induce vesicle swelling and fusion may have relevance for biological systems.
如果在磷脂囊泡的介质中用可渗透溶质取代不可渗透溶质后，与平面双层膜接触的囊泡发生渗透膨胀，那么磷脂囊泡就会与平面双层膜融合。这一发现直接表明，渗透膨胀是囊泡-平面膜融合的驱动力。用于诱导囊泡膨胀和融合的方法可能与生物系统相关。
