Maxwell I C, Le Quesne P M, Ekue J M, Biles J E
Neurotoxicology. 1981 Dec;2(4):687-701.
Muscle action potential amplitude recorded from abductor pollicis brevis in response to nerve stimulation was measured in 55 children during treatment of urinary schistosomiasis with metrifonate (3 doses at 2 weekly intervals). Mean erythrocyte cholinesterase activity was 52-75% of pretreatment value in different groups when examined electrophysiologically. Twenty-six children acted as controls. There was no difference in amplitude between control and exposed subjects 2 weeks after the 2nd dose. Six hours after the 3rd dose, amplitude was larger in some subjects. This effect was not related to dose or degree of cholinesterase inhibition and was thought unlikely to be the result of treatment. Three children who received the highest dose of metrifonate had developed repetitive activity 6 hr later. The criteria for its identification are described.
在55名儿童用敌百虫（每2周3剂）治疗尿路血吸虫病期间，测量了拇短展肌对神经刺激反应所记录的肌肉动作电位幅度。当进行电生理检查时，不同组的平均红细胞胆碱酯酶活性为治疗前值的52 - 75%。26名儿童作为对照。在第2剂后2周，对照组和暴露组之间的幅度没有差异。在第3剂后6小时，一些受试者的幅度更大。这种效应与剂量或胆碱酯酶抑制程度无关，被认为不太可能是治疗的结果。接受最高剂量敌百虫的3名儿童在6小时后出现了重复活动。描述了其识别标准。
