葡萄糖6-磷酸酶催化的磷酰基转移的立体化学过程。
The stereochemical course of phosphoryl transfer catalysed by glucose 6-phosphatase.
作者信息
Lowe G, Potter B V
出版信息
Biochem J. 1982 Mar 1;201(3):665-8. doi: 10.1042/bj2010665.
Abstract
Rat liver microsomal glucose 6-phosphatase catalyses phosphoryl transfer between D-glucose 6-[(R)-16O,17O,18O]phosphate and D-glucose with retention of configuration at the phosphorus atom. Since individual phosphoryl-transfer steps appear in general to occur with inversion of configuration, this observation is most simply interpreted in terms of a double-displacement mechanism with a phosphoryl-enzyme intermediate. Such an intermediate has been proposed previously from kinetic and 32P-labelling experiments.
摘要
大鼠肝脏微粒体葡萄糖6-磷酸酶催化D-葡萄糖6-[(R)-16O,17O,18O]磷酸酯与D-葡萄糖之间的磷酰基转移反应，磷原子构型保持不变。由于一般来说，各个磷酰基转移步骤似乎是构型翻转发生的，因此这一观察结果最简单的解释是存在一个带有磷酰化酶中间体的双置换机制。此前曾根据动力学和32P标记实验提出过这样一种中间体。
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本文引用的文献
1
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Science. 1960 Apr 1;131(3405):991-2. doi: 10.1126/science.131.3405.991.
2
Stereochemistry of phospho transfer catalyzed by bovine liver acid phosphatase.牛肝酸性磷酸酶催化的磷酸转移的立体化学
J Biol Chem. 1981 Oct 25;256(20):10453-5.
3
The stereochemical course of yeast hexokinase-catalysed phosphoryl transfer by using adenosine 5'[gamma(S)-16O,17O,18O]triphosphate as substrate.以腺苷5'-[γ(S)-16O,17O,18O]三磷酸为底物时酵母己糖激酶催化的磷酰基转移的立体化学过程。
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