麻疹病毒感染的选择性免疫抑制作用。
Selective immunosuppressive effects of measles virus infection.
作者信息
Pelton B K, Hylton W, Denman A M
出版信息
Clin Exp Immunol. 1982 Jan;47(1):19-26.
Abstract
The antibody response to diphtheria toxoid by cultured tonsil cells was suppressed by measles virus, which productively infected a small percentage of both T and B lymphocytes. However, infection of cultures spontaneously secreting antibody and immunoglobulin (with Herpes simplex virus) or measles virus did not result in immunosuppression. Immunosuppression by measles virus may thus be attributed to a selective effect on the inductive phase of the response and suggest that infection of immunoglobulin-producing B lymphocytes does not alter the ability of these cells to secrete antibody.
摘要
培养的扁桃体细胞对白喉类毒素的抗体反应受到麻疹病毒的抑制，麻疹病毒能有效感染一小部分T淋巴细胞和B淋巴细胞。然而，用单纯疱疹病毒或麻疹病毒感染自发分泌抗体和免疫球蛋白的培养物并未导致免疫抑制。因此，麻疹病毒引起的免疫抑制可能归因于对反应诱导期的选择性作用，这表明感染产生免疫球蛋白的B淋巴细胞并不会改变这些细胞分泌抗体的能力。
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