Pillai G K, McErlane K M
J Pharm Sci. 1982 May;71(5):583-5. doi: 10.1002/jps.2600710525.
A capillary gas-chromatographic method is described for the quantitative analysis of nine equine estrogens in a vaginal cream formulation. The sodium sulfate ethers of the estrogens were selectively extracted from the formulation, subjected to enzyme hydrolysis, and derivatized to their oxime-trimethylsilyl esters. Resolution of the resulting derivatives was achieved on short (15 m) capillary column, wall-coated with cyanopropylmethyl silicon stationary phase.
本文描述了一种毛细管气相色谱法，用于定量分析阴道乳膏制剂中的九种马雌激素。从制剂中选择性提取雌激素的硫酸钠盐醚，进行酶水解，并衍生化为肟-三甲基硅酯。所得衍生物在涂有氰丙基甲基硅固定相的短（15米）毛细管柱上实现分离。
