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元素硫：一种新型的腺苷酸激酶抑制剂。

Elemental sulfur: a novel inhibitor of adenylate kinase.

作者信息

Conner J, Russell P J

出版信息

Biochem Biophys Res Commun. 1983 May 31;113(1):348-52. doi: 10.1016/0006-291x(83)90472-2.

DOI:10.1016/0006-291x(83)90472-2
PMID:6305356
Abstract

Elementary sulfur (S-8) is a novel, highly specific and potent inhibitor of adenylate kinase (AK). The inhibition of AK by S-8 is completely reversed by dithiothreitol and is accompanied by several fold increases in enzymatic activity. Sulfhydryl group interaction with S-8 does not appear to be the mechanism of AK inhibitor and the results of comparative inhibition studies with N-ethyl maleimide (NEM) indicates that NEM also does not interact with the sulfhydryl group of AK.

摘要

元素硫（S-8）是一种新型、高度特异性且强效的腺苷酸激酶（AK）抑制剂。S-8对AK的抑制作用可被二硫苏糖醇完全逆转，并且伴随着酶活性增加数倍。硫氢基与S-8的相互作用似乎不是AK抑制剂的作用机制，与N-乙基马来酰亚胺（NEM）的比较抑制研究结果表明，NEM也不与AK的硫氢基相互作用。

相似文献

1
Elemental sulfur: a novel inhibitor of adenylate kinase.元素硫：一种新型的腺苷酸激酶抑制剂。
Biochem Biophys Res Commun. 1983 May 31;113(1):348-52. doi: 10.1016/0006-291x(83)90472-2.
2
Sulfur specifically inhibits adenylate kinase in assays for creatine kinase.在肌酸激酶检测中，硫会特异性抑制腺苷酸激酶。
Clin Chem. 1984 Sep;30(9):1555-7.
3
Characteristics of rabbit muscle adenylate kinase inhibition by sulfur and recovery by dithiothreitol.硫对兔肌肉腺苷酸激酶的抑制作用及二硫苏糖醇的恢复特性
J Enzyme Inhib. 1995;9(3):179-94. doi: 10.3109/14756369509021484.
4
Comparative inhibition patterns of adenylate kinases from mammals, bird, fish and microorganisms.哺乳动物、鸟类、鱼类和微生物中腺苷酸激酶的比较抑制模式。
Comp Biochem Physiol Biochem Mol Biol. 1994 Mar;107(3):489-94. doi: 10.1016/0305-0491(94)90215-1.
5
Species- or isozyme-specific enzyme inhibitors. 4. Design of a two-site inhibitor of adenylate kinase with isozyme selectivity.物种或同工酶特异性酶抑制剂。4. 具有同工酶选择性的腺苷酸激酶双位点抑制剂的设计。
J Med Chem. 1982 Jun;25(6):638-44. doi: 10.1021/jm00348a006.
6
Species- or isozyme-specific enzyme inhibitors. 7. Selective effects in inhibitions of rat adenylate kinase isozymes by adenosine 5'-phosphate derivatives.物种或同工酶特异性酶抑制剂。7. 5'-磷酸腺苷衍生物对大鼠腺苷酸激酶同工酶抑制作用的选择性效应。
J Med Chem. 1982 Jul;25(7):806-12. doi: 10.1021/jm00349a008.
7
Relative inhibition of human adenylate kinase and creatine kinase isoenzymes by adenosine 5'-monophosphate and diadenosine pentaphosphate.5'-单磷酸腺苷和二磷酸腺苷对人腺苷酸激酶和肌酸激酶同工酶的相对抑制作用。
Clin Chem. 1985 Feb;31(2):333-4.
8
Use of adenine nucleotide derivatives to assess the potential of exo-active-site-directed reagents as species- or isozyme-specific enzyme inactivators. 4. Interactions of adenosine 5'-triphosphate derivatives with adenylate kinases from Escherichia coli and rat tissues.使用腺嘌呤核苷酸衍生物评估外活性位点导向试剂作为物种或同工酶特异性酶失活剂的潜力。4. 腺苷5'-三磷酸衍生物与大肠杆菌和大鼠组织中的腺苷酸激酶的相互作用。
J Med Chem. 1982 Apr;25(4):382-6. doi: 10.1021/jm00346a010.
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Creatine kinase in serum: 3. Further study of adenylate kinase inhibitors.血清中的肌酸激酶：3. 腺苷酸激酶抑制剂的进一步研究。
Clin Chem. 1977 Oct;23(10):1888-92.
10
Studies on adenosine triphosphate transphosphorylases. Isolation and several properties of the crystalline calf ATP-AMP transphosphorylases (adenylate kinases) from muscle and liver and some observations on the rabbit muscle adenylate kinase.三磷酸腺苷转磷酸酶的研究。从肌肉和肝脏中分离出结晶小牛ATP-AMP转磷酸酶（腺苷酸激酶）及其若干特性，以及对兔肌肉腺苷酸激酶的一些观察。
Arch Biochem Biophys. 1978 Apr 15;187(1):34-52. doi: 10.1016/0003-9861(78)90004-8.

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