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猴病毒40的小t蛋白是大鼠细胞系中致密病灶形成所必需的。

Small t protein of simian virus 40 is required for dense focus formation in a rat cell line.

作者信息

Sugano S, Yamaguchi N, Shimojo H

出版信息

J Virol. 1982 Mar;41(3):1073-5. doi: 10.1128/JVI.41.3.1073-1075.1982.

DOI:10.1128/JVI.41.3.1073-1075.1982
PMID:6284962
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC256845/
Abstract

Incomplete foci were formed in a Fischer rat cell line infected with simian virus 40 detection mutants encoding defective small t antigen. The foci were small and rarely piled up. The fraction of DNA-synthesizing cells in the foci was about half of that induced by wild-type virus.

摘要

在感染了编码缺陷型小t抗原的猿猴病毒40检测突变体的费希尔大鼠细胞系中形成了不完全病灶。这些病灶很小，很少堆积。病灶中进行DNA合成的细胞比例约为野生型病毒诱导比例的一半。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/256845/addbd9fe1d7c/jvirol00162-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/256845/a7f590896f32/jvirol00162-0340-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/256845/addbd9fe1d7c/jvirol00162-0341-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/256845/a7f590896f32/jvirol00162-0340-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4fe7/256845/addbd9fe1d7c/jvirol00162-0341-a.jpg

相似文献

1
Small t protein of simian virus 40 is required for dense focus formation in a rat cell line.猴病毒40的小t蛋白是大鼠细胞系中致密病灶形成所必需的。
J Virol. 1982 Mar;41(3):1073-5. doi: 10.1128/JVI.41.3.1073-1075.1982.
2
Simian virus 40 small t antigen is not required for the maintenance of transformation but may act as a promoter (cocarcinogen) during establishment of transformation in resting rat cells.猴病毒40小t抗原对于维持转化并非必需，但在静止大鼠细胞转化的建立过程中可能作为一种促进剂（协同致癌物）发挥作用。
J Virol. 1979 Dec;32(3):979-88. doi: 10.1128/JVI.32.3.979-988.1979.
3
Simian virus 40 sequences between 0.168 and 0.424 map units are not required for abortive transformation.猿猴病毒40在0.168至0.424个图距单位之间的序列对于流产性转化并非必需。
J Virol. 1983 May;46(2):475-80. doi: 10.1128/JVI.46.2.475-480.1983.
4
A simian virus 40 dl884/tsA58 double mutant is temperature sensitive for abortive transformation.猿猴病毒40 dl884/tsA58双突变体对流产转化具有温度敏感性。
J Virol. 1983 May;46(2):620-5. doi: 10.1128/JVI.46.2.620-625.1983.
5
Study of the functional activities concomitantly retained by the 115,000 Mr super T antigen, an evolutionary variant of simian virus 40 large T antigen expressed in transformed rat cells.对115,000 Mr超级T抗原伴随保留的功能活性的研究，该抗原是在转化的大鼠细胞中表达的猿猴病毒40大T抗原的一种进化变体。
J Virol. 1983 Mar;45(3):901-13. doi: 10.1128/JVI.45.3.901-913.1983.
6
Effects of large and small T antigens on DNA synthesis and cell division in simian virus 40-transformed BALB/c 3T3 cells.大T抗原和小T抗原对猿猴病毒40转化的BALB/c 3T3细胞中DNA合成及细胞分裂的影响。
J Virol. 1982 Nov;44(2):574-85. doi: 10.1128/JVI.44.2.574-585.1982.
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Replication and transformation functions of in vitro-generated simian virus 40 large T antigen mutants.体外产生的猿猴病毒40大T抗原突变体的复制和转化功能
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Differential requirement for SV40 early genes in immortalization and transformation of primary rat and human embryonic cells.猿猴病毒40（SV40）早期基因在原代大鼠和人胚胎细胞永生化及转化中的差异需求。
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Cell surface T antigen in cells infected with simian virus 40 or an adenovirus-simian virus 40 hybrid, Ad2+D2.感染猴病毒40或腺病毒-猴病毒40杂交体Ad2+D2的细胞表面T抗原。
J Virol. 1981 Nov;40(2):615-9. doi: 10.1128/JVI.40.2.615-619.1981.
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94,000- and 100,000-molecular-weight simian virus 40 T-antigens are associated with the nuclear matrix in transformed and revertant mouse cells.94,000和100,000分子量的猿猴病毒40 T抗原与转化的和回复突变的小鼠细胞中的核基质相关联。
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Induction of p53-independent apoptosis by simian virus 40 small t antigen.猿猴病毒40小t抗原诱导不依赖p53的细胞凋亡。

本文引用的文献

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Association of simian virus 40 T antigen with replicating nucleoprotein complexes of simian virus 40.猿猴病毒40 T抗原与猿猴病毒40复制性核蛋白复合物的关联。
J Virol. 1980 Aug;35(2):320-30. doi: 10.1128/JVI.35.2.320-330.1980.
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The small-t protein of SV40 is required for loss of actin cable networks and plasminogen activator synthesis in transformed rat cells.SV40的小t蛋白是转化大鼠细胞中肌动蛋白丝网络丧失和纤溶酶原激活物合成所必需的。
Virology. 1980 Oct 30;106(2):282-91. doi: 10.1016/0042-6822(80)90251-2.
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Anchorage independence: analysis of factors affecting the growth and colony formation of wild-type and dl 54/59 mutant SV40-transformed lines.
J Virol. 2001 Oct;75(19):9142-55. doi: 10.1128/JVI.75.19.9142-9155.2001.
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pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression.猿猴病毒40大T抗原在克服p53生长抑制中的pRB依赖性、J结构域非依赖性功能。
J Virol. 2000 Jan;74(2):864-74. doi: 10.1128/jvi.74.2.864-874.2000.
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The simian virus 40 small-t and large-T antigens jointly regulate cell cycle reentry in human fibroblasts.猿猴病毒40小t抗原和大T抗原共同调节人成纤维细胞的细胞周期重新进入。
J Virol. 1999 Apr;73(4):3102-7. doi: 10.1128/JVI.73.4.3102-3107.1999.
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Cell cycle progression in monkey cells expressing simian virus 40 small t antigen from adenovirus vectors.在通过腺病毒载体表达猿猴病毒40小t抗原的猴细胞中的细胞周期进程。
J Virol. 1998 Dec;72(12):9637-44. doi: 10.1128/JVI.72.12.9637-9644.1998.
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Dissociation of retinoblastoma gene protein hyperphosphorylation and commitment to enter S phase.视网膜母细胞瘤基因蛋白的过度磷酸化与进入S期的决定因素的解离。
J Virol. 1994 Jun;68(6):3724-32. doi: 10.1128/JVI.68.6.3724-3732.1994.
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Purification of biologically active simian virus 40 small tumor antigen.生物活性猿猴病毒40小肿瘤抗原的纯化
Proc Natl Acad Sci U S A. 1983 Feb;80(4):906-10. doi: 10.1073/pnas.80.4.906.
9
Monoclonal antibody to simian virus 40 small t.针对猴病毒40小t抗原的单克隆抗体
J Virol. 1984 Sep;51(3):760-7. doi: 10.1128/JVI.51.3.760-767.1984.
10
Simian virus 40 small tumor antigen and an amino-terminal domain of large tumor antigen share a common transforming function.猿猴病毒40小肿瘤抗原和大肿瘤抗原的氨基末端结构域具有共同的转化功能。
Proc Natl Acad Sci U S A. 1990 Oct;87(19):7448-52. doi: 10.1073/pnas.87.19.7448.
锚定非依赖性：影响野生型和dl 54/59突变型SV40转化细胞系生长和集落形成的因素分析。
Virology. 1979 Dec;99(2):302-11. doi: 10.1016/0042-6822(79)90009-6.
4
Simian virus 40 small t antigen is not required for the maintenance of transformation but may act as a promoter (cocarcinogen) during establishment of transformation in resting rat cells.猴病毒40小t抗原对于维持转化并非必需，但在静止大鼠细胞转化的建立过程中可能作为一种促进剂（协同致癌物）发挥作用。
J Virol. 1979 Dec;32(3):979-88. doi: 10.1128/JVI.32.3.979-988.1979.
5
New region of the simian virus 40 genome required for efficient viral transformation.猿猴病毒40高效病毒转化所需的基因组新区域。
Proc Natl Acad Sci U S A. 1978 May;75(5):2473-7. doi: 10.1073/pnas.75.5.2473.
6
Mutants of SV40 with an altered small t protein are reduced in their ability to transform cells.小t蛋白发生改变的SV40突变体转化细胞的能力降低。
Cell. 1978 May;14(1):79-88. doi: 10.1016/0092-8674(78)90303-3.
7
Organization and expression of early genes of simian virus 40.猴病毒40早期基因的组织与表达
Proc Natl Acad Sci U S A. 1978 Jan;75(1):117-21. doi: 10.1073/pnas.75.1.117.
8
Construction and analysis of viable deletion mutants of simian virus 40.猿猴病毒40型活缺失突变体的构建与分析
J Virol. 1976 May;18(2):664-71. doi: 10.1128/JVI.18.2.664-671.1976.
9
Rat cell line 3y1 and its virogenic polyoma- and sv40- transformed derivatives.大鼠细胞系3y1及其病毒源性多瘤病毒和猿猴空泡病毒40转化的衍生物。
Int J Cancer. 1975 Apr 15;15(4):694-706. doi: 10.1002/ijc.2910150419.