Witzmann A, Jellinger K, Weiss R
Neurochirurgia (Stuttg). 1981 Nov;24(6):202-6. doi: 10.1055/s-2008-1054068.
We report the case of a 28-year-old male who suffered a frontal penetrating gunshot injury with subsequent bifrontal brain abscess and subdural empyema, and five years later developed a large bifrontal tumour at the precise site of the meningo-cerebral scar and posttraumatic defect. Histological examination showed a glioblastoma multiforme adjacent to the dural scar and, in addition, old suture material was found within the glioma tissue. In spite of combined radiation and polychemotherapy the patient died eleven months after partial tumour resection. The temporal and local association of missile injury with subsequent recurred abscess and scar formation and the malignant glioma is highly suggestive of a causal relationship between trauma and the development of a brain tumour.
我们报告了一例28岁男性患者，其遭受额部穿透性枪伤，随后出现双侧额叶脑脓肿和硬膜下积脓，五年后在脑膜脑瘢痕和创伤后缺损的精确部位出现一个巨大的双侧额叶肿瘤。组织学检查显示，在硬脑膜瘢痕附近有一个多形性胶质母细胞瘤，此外，在胶质瘤组织内发现了陈旧的缝线材料。尽管进行了联合放疗和多药化疗，患者在肿瘤部分切除术后11个月死亡。导弹伤与随后反复出现的脓肿、瘢痕形成以及恶性胶质瘤在时间和局部上的关联，强烈提示创伤与脑肿瘤发生之间存在因果关系。
