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猪蛔虫中的染色质消减:被消除的卫星DNA的核苷酸序列。

Chromatin diminution in Ascaris suum: nucleotide sequence of the eliminated satellite DNA.

作者信息

Streeck R E, Moritz K B, Beer K

出版信息

Nucleic Acids Res. 1982 Jun 11;10(11):3495-502. doi: 10.1093/nar/10.11.3495.

Abstract

We have determined the prototype sequence of the DNA which is eliminated in the course of chromatin diminution in Ascaris suum. This DNA which is virtually absent from somatic cells but retained in the germ line consists predominantly of highly repetitive sequences which are variants of an AT rich 123 base pair repeat unit. Both major and minor variants have been sequenced. The overall structure of this germ line limited DNA corresponds to the segmental organization characteristic of satellite DNAs. Possible correlations between the mechanism of chromatin diminution and some properties of the satellite sequence are discussed.

摘要

我们已经确定了猪蛔虫染色质消减过程中被消除的DNA的原型序列。这种DNA在体细胞中几乎不存在,但保留在生殖系中,主要由高度重复序列组成,这些序列是富含AT的123个碱基对重复单元的变体。主要和次要变体均已测序。这种生殖系受限DNA的整体结构与卫星DNA的分段组织特征相对应。本文讨论了染色质消减机制与卫星序列某些特性之间可能存在的关联。

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