Coustan D R, Lewis S B
Obstet Gynecol. 1978 Mar;51(3):306-10. doi: 10.1097/00006250-197803000-00010.
Seventy-two patient with gestational diabetes were randomly treated with insulin (20 units NPH and 10 units regular) and diabetic diet, diet alone, or neither. Of the 27 patients treated with insulin and diet, 2 (7%) had babies weighing more than 8 1/2 pounds. Of the 11 patients treated with diet alone, 4 (36.4%) had babies weighing more than 8 1/2 pounds. Of the 34 patients treated with neither diet nor insulin, 17 (50%) had babies weighing more than 8 1/2 pounds. These data support the hypothesis that treatment of the gestational diabetic with insulin will reduce the incidence of fetal macrosomia.
72例妊娠糖尿病患者被随机分为三组，分别接受胰岛素（20单位中效胰岛素和10单位正规胰岛素）加糖尿病饮食治疗、单纯饮食治疗或不进行任何治疗。在接受胰岛素加饮食治疗的27例患者中，有2例（7%）婴儿体重超过8.5磅。在单纯接受饮食治疗的11例患者中，有4例（36.4%）婴儿体重超过8.5磅。在既未接受饮食治疗也未接受胰岛素治疗的34例患者中，有17例（50%）婴儿体重超过8.5磅。这些数据支持了用胰岛素治疗妊娠糖尿病会降低巨大儿发生率这一假说。
