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吸入镉微粒对小鼠空气传播细菌感染和空气传播病毒感染易感性的相反影响。

Opposite effects of inhaled cadmium microparticles on mouse susceptibility to an airborne bacterial and an airborne viral infection.

作者信息

Bouley G, Chaumard C, Quero A M, Girard F, Boudene C

出版信息

Sci Total Environ. 1982 Apr;23:185-8. doi: 10.1016/0048-9697(82)90134-6.

Abstract

An experimental study on 489 mice is reported. The test animals were submitted to a single 15-mn exposure to atmosphere containing about 10 mg of cadmium microparticles (CdO) per m3 of air and the controls to an equivalent amount of aluminium microparticles (Al2o3). At the 48th hour after exposures, the test and control mice were submitted to a bacterial (Pasteurella multocida) or to a viral (Orthomyxovirus influenzae A) challenge, via the respiratory route. The exposure to cadmium significantly increased the death-rate of mice submitted to the bacterial challenge, but it significantly decreased the death-rate following the viral challenge.

摘要

报道了一项对489只小鼠的实验研究。将实验动物暴露于每立方米空气中含有约10毫克镉微粒(CdO)的大气中15分钟,对照组则暴露于等量的铝微粒(Al2O3)中。在暴露后第48小时,通过呼吸道途径对实验小鼠和对照小鼠进行细菌(多杀巴斯德菌)或病毒(甲型流感病毒)攻击。镉暴露显著增加了遭受细菌攻击的小鼠的死亡率,但显著降低了病毒攻击后的死亡率。

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