Soike K F, Gerone P J
Am J Med. 1982 Jul 20;73(1A):112-7. doi: 10.1016/0002-9343(82)90075-4.
Acyclovir (9-(2-hydroxyethoxymethyl)guanine) administered as an intramuscular formulation twice daily at a dosage of 100 mg/kg per day prevented the development of disease in African green monkeys inoculated with simian varicella virus. Viremia, appearance of a vesicular rash, and elevations of serum transaminases, each indicative of infection, were suppressed by acyclovir treatment. Plasma concentrations of acyclovir were measured and showed rising levels after repeated intramuscular injection with a prolonged period of absorption of acyclovir into the plasma circulation. Investigation of antiviral efficacy after either intramuscular or intravenous acyclovir treatment showed both routes of administration to be effective in inhibiting simian varicella virus infection at the 100 mg/kg per day level. However, intravenous acyclovir 50 mg/kg twice daily did result in elevated values of blood urea nitrogen, creatinine, and serum transaminases.
阿昔洛韦（9 -（2 - 羟乙氧甲基）鸟嘌呤）以每天100毫克/千克的剂量分两次肌肉注射给药，可预防接种猴水痘病毒的非洲绿猴发病。阿昔洛韦治疗可抑制病毒血症、水疱性皮疹的出现以及血清转氨酶升高，这些均表明感染得到了抑制。对阿昔洛韦的血浆浓度进行了测定，结果显示反复肌肉注射后血浆浓度升高，且阿昔洛韦吸收进入血液循环的时间延长。对肌肉注射或静脉注射阿昔洛韦治疗后的抗病毒疗效进行研究表明，两种给药途径在每天100毫克/千克的剂量水平下均能有效抑制猴水痘病毒感染。然而，每天两次静脉注射50毫克/千克的阿昔洛韦确实导致血尿素氮、肌酐和血清转氨酶值升高。
