Bertagna X, Luton J P, Bricaire H
Ann Med Interne (Paris). 1982;133(3):145-7.
beta-Endorphin, a pituitary morphino-mimetic peptide, was identified in a culture medium derived from a human corticotropic adenoma. Secretion products from cultured human cells derived from a small-cell carcinoma of the lung were shown to contain a high molecular weight precursor analagous to pro-opiocortin: this molecule is a polypeptide of the order of 28,000 daltons the enzymatic processing of which leads to the coordinated and simultaneous release of different peptide fragments: ACTH, beta- and gamma-lipotropins, beta-endorphin, fragment 16 K and gamma 3-MSH. All these peptides have been identified in human plasma, and pituitary and non-pituitary tumor extracts. Their plasma concentrations vary in a parallel manner, beta-endorphin and a peptide very similar to beta-MSH have been detected in human hypothalamus.
β-内啡肽是一种垂体类吗啡样肽，在源自人促肾上腺皮质激素腺瘤的培养基中被鉴定出来。来自人肺小细胞癌的培养细胞的分泌产物显示含有一种与阿片促皮质素原类似的高分子量前体：该分子是一种约28,000道尔顿的多肽，其酶促加工导致不同肽片段（促肾上腺皮质激素、β-和γ-促脂素、β-内啡肽、16K片段和γ3-促黑素细胞激素）的协同和同时释放。所有这些肽已在人血浆、垂体和非垂体肿瘤提取物中被鉴定出来。它们的血浆浓度以平行方式变化，在人下丘脑已检测到β-内啡肽和一种与β-促黑素细胞激素非常相似的肽。
