Sumner A J, Saida K, Saida T, Silberberg D H, Asbury A K
Ann Neurol. 1982 May;11(5):469-77. doi: 10.1002/ana.410110506.
Intraneural injection of antisera from rabbits with high antigalactocerebroside antibody levels into rat sciatic nerve produced acute nerve conduction block. This was first apparent in some motor axons between 30 and 60 minutes after injection and progressed to completion within 2 to 4 hours. Concurrent morphological evidence of demyelination was present, but structural changes at the time of onset of block were mild and were restricted to the myelin and Schwann cell, particularly at the paranodal areas and Schmidt-Lanterman clefts. It is suggested that paranodal lesions could account for the observed conduction block.
将来自具有高抗半乳糖脑苷脂抗体水平的兔子的抗血清注射到大鼠坐骨神经内会导致急性神经传导阻滞。这种阻滞在注射后30至60分钟时首先在一些运动轴突中显现出来，并在2至4小时内发展至完全阻滞。同时存在脱髓鞘的形态学证据，但在阻滞开始时的结构变化很轻微，且仅限于髓鞘和施万细胞，特别是在结旁区和施密特-兰特尔曼切迹处。有人提出结旁病变可能是观察到的传导阻滞的原因。
