脑室内注射的神经肽在外周循环中的快速出现。
Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation.
作者信息
Passaro E, Debas H, Oldendorf W, Yamada T
出版信息
Brain Res. 1982 Jun 10;241(2):335-40.
PMID:6286044
Abstract
125I-Labeled cholecystokinin octapeptide ([125I]CCK-OP) diffuses rapidly by a non-carrier-mediated mechanism into the peripheral blood following injection into the lateral ventricle of a rabbit. In contrast, no [125I]CCK-OP was observed in the CSF following intravenous injection. This unidirectional free transport mechanism from CSF to blood may apply to other neuropeptides as well.
摘要
将125I标记的胆囊收缩素八肽（[125I]CCK-OP）注入兔侧脑室后，它通过非载体介导机制迅速扩散到外周血中。相比之下，静脉注射后在脑脊液中未观察到[125I]CCK-OP。这种从脑脊液到血液的单向自由转运机制可能也适用于其他神经肽。
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