经胎盘途径获得的缺陷型细小病毒可保护小鼠免受致死性腺病毒感染。
Defective parvoviruses acquired via the transplacental route protect mice against lethal adenovirus infection.
作者信息
Lipps B V, Mayor H D
出版信息
Infect Immun. 1982 Jul;37(1):200-4. doi: 10.1128/iai.37.1.200-204.1982.
Abstract
Adeno-associated virus type 1 (AAV-1) interfered with the replication of its murine adenovirus (MAV) helper in primary mouse kidney cells and in 1-day-old ICR mice. Mice carrying AAV-1 acquired via the transplacental route were protected against lethal infection with MAV. The replication of AAV-1 in these mice could be triggered by multiple challenges with MAV, and antibodies to AAV-1 were subsequently detected.
摘要
1型腺相关病毒（AAV-1）在原代小鼠肾细胞和1日龄ICR小鼠中干扰其鼠腺病毒（MAV）辅助病毒的复制。经胎盘途径感染AAV-1的小鼠可免受MAV致死性感染。在这些小鼠中，AAV-1的复制可由MAV的多次攻击触发，随后可检测到抗AAV-1抗体。
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