小鼠中1型腺相关病毒的经胎盘感染。
Transplacental infection with adeno-associated virus type 1 in mice.
作者信息
Lipps B V, Mayor H D
出版信息
Intervirology. 1980;14(2):118-23. doi: 10.1159/000149172.
PMID:6259087
Abstract
Adeno-associated type 1 parvovirus (AAV) was detected in the kidneys and lungs of fetuses and newborns, when pregnant mice were injected subcutaneously with AAV type 1 and murine adenovirus as a helper virus. These findings clearly indicate that transplacental infection with AAV in rodents has been achieved.
摘要
当给怀孕小鼠皮下注射1型腺相关细小病毒（AAV）和作为辅助病毒的鼠腺病毒时，在胎儿和新生儿的肾脏和肺中检测到了1型腺相关细小病毒。这些发现清楚地表明，在啮齿动物中已实现AAV的经胎盘感染。
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