Hodes D S
J Gen Virol. 1982 Jun;60(Pt 2):401-4. doi: 10.1099/0022-1317-60-2-401.
Vero cells persistently infected with parainfluenza virus type 3 (para 3) were examined for the production of temperature-sensitive (ts) mutants. After 6 months and 33 passages, ts mutants formed the great majority of the virus being shed into the supernatant fluid. Complementation studies gave evidence that the mutants shared a common lesion. Although ts mutants may play a role in the maintenance of persistent infection in this system, the mutants proved to be unstable when removed from the milieu of persistent infection. It is thus possible that their selection may be secondary to (an) unidentified factor(s) which play(s) a more primary role in the maintenance process.
对持续感染3型副流感病毒（副流感病毒3型）的非洲绿猴肾细胞（Vero细胞）进行了温度敏感（ts）突变体产生情况的检测。6个月及传代33次后，ts突变体构成了释放到上清液中的绝大多数病毒。互补试验表明这些突变体存在共同损伤。虽然ts突变体可能在该系统持续性感染的维持中发挥作用，但这些突变体在脱离持续性感染环境后被证明是不稳定的。因此，它们的选择可能继发于在维持过程中起更主要作用的一个（或一些）未明确的因素。
