Hodes D S, Weldy P L, Doundoulakis J H
J Gen Virol. 1979 Aug;44(2):515-23. doi: 10.1099/0022-1317-44-2-515.
A strain of parainfluenza virus type 3 (para 3) that had undergone a series of undiluted passages failed to produce syncytia when inoculated on to Vero cells at a high m.o.i. The strain repeatedly produced stable persistent infections. Persistently infected cells were resistant to superinfection by homologous virus, showed the presence of virus-specific antigen and shed low quantities of infectious virus into the supernatant fluid. The undiluted passage parainfluenza virus type 3 strain produced a substance that inhibited syncytium formation by homologous virus and by measles virus but appeared to have no effect on virus replication. This inhibitor had no demonstrable effect on unrelated viruses, including some that produced syncytia. It had a mol. wt. between 3500 and 14000, was acid- and heat-labile, and was inactivated by anti-para 3 serum.
一株经过一系列未稀释传代的副流感病毒3型（副3型），以高感染复数接种到Vero细胞上时未能产生多核巨细胞。该毒株反复产生稳定的持续性感染。持续感染的细胞对同源病毒的超感染具有抗性，显示出病毒特异性抗原的存在，并向上清液中释放少量传染性病毒。未稀释传代的副流感病毒3型毒株产生了一种物质，该物质可抑制同源病毒和麻疹病毒形成多核巨细胞，但似乎对病毒复制没有影响。这种抑制剂对包括一些能产生多核巨细胞的无关病毒没有明显作用。它的分子量在3500至14000之间，对酸和热不稳定，并被抗副3型血清灭活。
