Lotz W
Neuroendocrinology. 1982;35(1):32-6. doi: 10.1159/000123351.
A number of centrally active benzodiazepines lowered baseline serum prolactin concentrations after oral administration to male rats. The increase of circulating prolactin levels elicited by oral administration of various neuroleptic agents was also reduced by prior or simultaneous oral administration of several benzodiazepines in a dose-dependent manner. Since both effects were prevented by simultaneous administration of the benzodiazepine antagonist Ro 15-1788 they are probably mediated by central benzodiazepine receptors which interfere with aminergic mechanisms governing serum prolactin.
给雄性大鼠口服多种中枢活性苯二氮䓬类药物后，其血清催乳素基线浓度降低。预先或同时口服几种苯二氮䓬类药物，也会以剂量依赖的方式降低各种抗精神病药物口服给药引起的循环催乳素水平升高。由于同时给予苯二氮䓬类拮抗剂Ro 15-1788可阻止这两种效应，因此它们可能是由中枢苯二氮䓬受体介导的，该受体干扰了控制血清催乳素的胺能机制。
