Little H J, Taylor S C, Nutt D J, Cowen P J
Eur J Pharmacol. 1985 Jan 8;107(3):375-7. doi: 10.1016/0014-2999(85)90265-1.
The effects of the benzodiazepine antagonist, Ro 15-1788 on ethanol withdrawal convulsions were investigated in rats. The study originated from recent reports of benzodiazepine binding activity in urine of alcoholics during withdrawal. No alleviation of convulsions was found with Ro 15-1788. This suggested that this component of the withdrawal syndrome is not due to endogenous production of a benzodiazepine inverse agonist (contragonist), as Ro 15-1788 prevents the action of this type of compound.
研究了苯二氮䓬拮抗剂Ro 15 - 1788对大鼠乙醇戒断惊厥的影响。该研究源于近期关于戒酒期间酗酒者尿液中苯二氮䓬结合活性的报道。未发现Ro 15 - 1788能缓解惊厥。这表明戒断综合征的这一成分并非内源性产生苯二氮䓬反向激动剂（抗拮抗剂）所致，因为Ro 15 - 1788可阻止这类化合物的作用。
