Sanderson D, Fontana R
Recent Results Cancer Res. 1982;82:179-86. doi: 10.1007/978-3-642-81768-7_19.
Screening for lung cancer by chest roentgenography and sputum cytology can be conducted by mail. Detection, localization, and treatment of early presymptomatic lesions are possible. The initial prevalence of lung cancer in men older than age 45 years who were heavy smokers was almost 1%. Rescreening at 4-monthly intervals detected 4.7 new cases of lung cancer per 1,000 subjects per year. Three times as many postsurgical stage I lesions were detected in the screened group as in the control group. Although survival seems to have been improved by screening, mortality from lung cancer is not yet significantly different in the 4-monthly surveillance and control groups. Longer follow-up is necessary for determination of the ultimate usefulness of screening.
通过胸部X线摄影和痰细胞学检查进行肺癌筛查可通过邮寄方式开展。对早期无症状病变进行检测、定位和治疗是可行的。年龄超过45岁的重度吸烟男性中肺癌的初始患病率近1%。每隔4个月进行一次复查，每年每1000名受检者中可检测到4.7例新发肺癌病例。筛查组检测出的术后I期病变数量是对照组的三倍。虽然筛查似乎改善了生存率，但在每4个月进行一次监测的组和对照组中，肺癌死亡率尚无显著差异。需要更长时间的随访来确定筛查的最终效用。
