Fontana R S, Sanderson D R, Taylor W F, Woolner L B, Miller W E, Muhm J R, Uhlenhopp M A
Am Rev Respir Dis. 1984 Oct;130(4):561-5. doi: 10.1164/arrd.1984.130.4.561.
The initial (prevalence) radiologic and cytologic screening for lung cancer in the Mayo Clinic study (Mayo Lung Project) involved 10,933 outpatients. All were men at high risk for lung cancer, but none were suspected of having it when they entered the Mayo Clinic. Screening identified 91 lung cancers (8.3 per 1,000 screened). Nearly two thirds of the prevalence lung cancers were detected by chest roentgenography alone. Half of these cancers were resected. Only a fifth of the cancers were detected by sputum cytologic examination alone; however, all but 1 of these were resected. Compared with a group of lung cancers encountered in contemporary clinical practice at the Mayo Clinic, the prevalence cancers were more than twice as likely to be (1) resectable, (2) postsurgical Stage I or II (AJCC), and (3) associated with survival 5 yr after treatment.
梅奥诊所研究（梅奥肺癌项目）中针对肺癌的初始（患病率）放射学和细胞学筛查涉及10933名门诊患者。所有患者均为肺癌高危男性，但进入梅奥诊所时均未被怀疑患有肺癌。筛查发现了91例肺癌（每1000名接受筛查者中有8.3例）。近三分之二的患病率肺癌仅通过胸部X线检查发现。其中一半的癌症接受了切除。仅通过痰细胞学检查发现的癌症占五分之一；然而，除1例之外，所有这些癌症均接受了切除。与梅奥诊所当代临床实践中遇到的一组肺癌相比，患病率癌症更有可能出现以下情况：（1）可切除，（2）术后为I期或II期（美国癌症联合委员会），以及（3）与治疗后5年生存率相关，可能性是前者的两倍多。
