Melli M, Türker R K
Arch Int Pharmacodyn Ther. 1982 May;257(1):87-93.
The conversion of angiotensin I to angiotensin II was studied in the isolated perfused hindquarters of guinea-pig. The relative enzyme activity was determined by vasoconstrictor response to the peptides and by the contraction of rat ascending colon superfused with the venous effluent. 45% of conversion of angiotensin I to angiotensin II was determined in this preparation as measured by vasoconstrictor responses. However, only 22% of conversion was detected in the venous return as measured in the rat colon. Captopril significantly inhibited angiotensin converting enzyme activity in this preparation. Acetylsalicylic acid, however, partially prevented the inhibitory effect of Captopril on converting enzyme activity in this vascular bed. The possible interactions of angiotensin converting enzyme activity and endogenous prostaglandins are discussed.
在豚鼠离体灌注后肢中研究了血管紧张素I向血管紧张素II的转化。通过对肽的血管收缩反应以及用静脉流出液灌流的大鼠升结肠的收缩来测定相对酶活性。通过血管收缩反应测定，该制剂中血管紧张素I向血管紧张素II的转化率为45%。然而，在大鼠结肠中测定的静脉回流中仅检测到22%的转化率。卡托普利在该制剂中显著抑制血管紧张素转换酶活性。然而，乙酰水杨酸部分地阻止了卡托普利对该血管床中转换酶活性的抑制作用。讨论了血管紧张素转换酶活性与内源性前列腺素之间可能的相互作用。
