Lowe J R, Dixon J S, Guthrie J A, McWhinney P
Ann Rheum Dis. 1986 Nov;45(11):921-4. doi: 10.1136/ard.45.11.921.
Serum levels of angiotensin converting enzyme (ACE) activity in patients with rheumatoid arthritis (RA) (n = 48), osteoarthritis (OA) (n = 11), ankylosing spondylitis (n = 24), psoriatic arthritis (n = 12), and Behçet's syndrome (n = 20) were not significantly different from those of normal controls (n = 26). Synovial fluid ACE activity was lower in OA than in RA but was similar when corrected for protein levels. An increase in serum ACE concentration in patients with RA receiving captopril therapy is in agreement with previous results. There was some correlation of ACE with erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) but not with clinical indices in captopril treated patients. It is suggested that the beneficial actions of captopril in the treatment of RA are not due to its activity as an ACE inhibitor, but more probably a result of captopril being an aliphatic thiol.
类风湿关节炎（RA）患者（n = 48）、骨关节炎（OA）患者（n = 11）、强直性脊柱炎患者（n = 24）、银屑病关节炎患者（n = 12）和白塞病患者（n = 20）的血清血管紧张素转换酶（ACE）活性水平与正常对照组（n = 26）相比无显著差异。OA患者滑液中的ACE活性低于RA患者，但校正蛋白质水平后二者相似。接受卡托普利治疗的RA患者血清ACE浓度升高与先前结果一致。在接受卡托普利治疗的患者中，ACE与红细胞沉降率（ESR）和C反应蛋白（CRP）存在一定相关性，但与临床指标无关。提示卡托普利治疗RA的有益作用并非因其作为ACE抑制剂的活性，而更可能是由于卡托普利是一种脂肪族硫醇。
