Liang Y O, Wightman R M, Adams R N
Eur J Pharmacol. 1976 Apr;36(2):455-8. doi: 10.1016/0014-2999(76)90102-3.
Simultaneous oxygen electrode and conventional polarographic measurements show the net concentration of hydrogen peroxide produced by air oxidation of 6-hydroxydopamine is considerably less than that predicted from the known stoichiometry of the reaction. This is due to competitive oxidation of 6-hydroxydopamine by the generated hydrogen peroxide. The presence of ascorbic acid in this reaction also results in significant decreases of hydrogen peroxide under most conditions. The implications of these results to the molecular mechanism of 6-hydroxydopamine neurotoxicity are discussed.
同时进行的氧电极和传统极谱测量表明，6-羟基多巴胺空气氧化产生的过氧化氢净浓度远低于根据已知反应化学计量预测的浓度。这是由于生成的过氧化氢对6-羟基多巴胺的竞争性氧化。该反应中抗坏血酸的存在在大多数情况下也会导致过氧化氢显著减少。讨论了这些结果对6-羟基多巴胺神经毒性分子机制的影响。
