毛喉素作为一种激活丽蝇唾液腺中环磷酸腺苷积累和分泌的物质。
Forskolin as an activator of cyclic AMP accumulation and secretion in blowfly salivary glands.
作者信息
Litosch I, Saito Y, Fain J N
出版信息
Biochem J. 1982 Apr 15;204(1):147-51. doi: 10.1042/bj2040147.
Abstract
Forskolin is a diterpene that activates adenylate cyclase in a variety of mammalian cells. In addition of forskolin to blowfly salivary glands increased cyclic AMP accumulation and salivary secretion. There was a small increase in transepithelial movement of labelled Ca2+. Forskolin did not induce breakdown of labelled phosphatidylinositol or inhibit the stimulation of phosphatidylinositol breakdown caused by 5-hydroxytryptamine. These data indicate that forskolin can mimic all the effects of 5-hydroxytryptamine on salivary-gland secretion that have been attributed to cyclic AMP.
摘要
福斯高林是一种二萜类化合物，可激活多种哺乳动物细胞中的腺苷酸环化酶。将福斯高林添加到丽蝇唾液腺中可增加环磷酸腺苷（cAMP）的积累和唾液分泌。标记的钙离子（Ca2+）的跨上皮运动略有增加。福斯高林不会诱导标记的磷脂酰肌醇分解，也不会抑制5-羟色胺引起的磷脂酰肌醇分解刺激。这些数据表明，福斯高林可以模拟5-羟色胺对唾液腺分泌的所有归因于环磷酸腺苷的作用。
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本文引用的文献
1
Regulation of adenylate cyclase and cyclic AMP phosphodiesterase by 5-hydroxytryptamine and calcium ions in blowfly salivary-gland homogenates.5-羟色胺和钙离子对丽蝇唾液腺匀浆中腺苷酸环化酶和环磷酸腺苷磷酸二酯酶的调节作用
Biochem J. 1982 Apr 15;204(1):153-9. doi: 10.1042/bj2040153.
2
Changes in cyclic AMP and cyclic GMP concentrations during the action of 5-hydroxytryptamine on an insect salivary gland.5-羟色胺作用于昆虫唾液腺过程中环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）浓度的变化
Biochem J. 1980 Oct 15;192(1):247-55. doi: 10.1042/bj1920247.
3
Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.福斯高林：膜及完整细胞中独特的腺苷酸环化酶二萜激活剂。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3363-7. doi: 10.1073/pnas.78.6.3363.
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Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion.钙和3':5'-环磷酸腺苷在控制果蝇唾液腺分泌中的作用。
Proc Natl Acad Sci U S A. 1972 Mar;69(3):553-7. doi: 10.1073/pnas.69.3.553.
5
The role of 5-hydroxytryptamine and cyclic AMP in the control of fluid secretion by isolated salivary glands.5-羟色胺和环磷酸腺苷在离体唾液腺液体分泌控制中的作用。
J Exp Biol. 1970 Aug;53(1):171-86. doi: 10.1242/jeb.53.1.171.
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Stimulus-secretion coupling in an insect salivary gland: cell activation by elevated potassium concentrations.昆虫唾液腺中的刺激-分泌偶联：钾离子浓度升高引起的细胞激活。
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