钙和3':5'-环磷酸腺苷在控制果蝇唾液腺分泌中的作用。
Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion.
作者信息
Prince W T, Berridge M J, Rasmussen H
出版信息
Proc Natl Acad Sci U S A. 1972 Mar;69(3):553-7. doi: 10.1073/pnas.69.3.553.
Abstract
The action of 5-hydroxytryptamine (5-HT) on an insect salivary gland was associated with a rise in adenosine-3':5'-cyclic monophosphate (cAMP) concentration and an increase in calcium uptake. An increase in secretion induced either by 5-HT or exogenous cAMP required extracellular calcium. Both 5-HT and exogenous cAMP increased (45)Ca efflux from previously labeled glands, but only 5-HT caused an increase in calcium uptake. The transepithelial potential in this tissue became more negative after addition of 5-HT, but more positive after addition of cAMP. 5-HT and cAMP induced a more negative potential when calcium was removed from the medium. It was concluded that both calcium and cAMP serve as intracellular messengers when 5-HT acts upon fly salivary gland.
摘要
5-羟色胺（5-HT）对昆虫唾液腺的作用与3':5'-环磷酸腺苷（cAMP）浓度升高及钙摄取增加有关。5-HT或外源性cAMP诱导的分泌增加需要细胞外钙。5-HT和外源性cAMP均增加了先前标记腺体的（45）Ca外流，但只有5-HT导致钙摄取增加。添加5-HT后，该组织的跨上皮电位变得更负，但添加cAMP后则更正。当从培养基中去除钙时，5-HT和cAMP诱导的电位更负。得出的结论是，当5-HT作用于果蝇唾液腺时，钙和cAMP均作为细胞内信使。
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