Studler J M, Javoy-Agid F, Cesselin F, Legrand J C, Agid Y
Brain Res. 1982 Jul 8;243(1):176-9. doi: 10.1016/0006-8993(82)91135-0.
The regional distribution of immunoassayable CCK-8 was determined in 12 regions of control and parkinsonian human brain, with specific attention to the possible regional coexistence of CCK-8 with dopamine. In Parkinson's disease, CCK-8-I levels were only decreased in the substantia nigra where dopamine cell bodies lie, and not in striatal and corticolimbic dopamine projecting areas. Our results suggest that the major proportion of dopaminergic neurones degenerated in Parkinson's disease may not contain the CCK-8 peptide.
在对照和帕金森病患者的人脑12个区域中测定了可免疫检测的CCK-8的区域分布，特别关注CCK-8与多巴胺可能的区域共存情况。在帕金森病中，CCK-8-I水平仅在多巴胺细胞体所在的黑质中降低，而在纹状体和皮质边缘多巴胺投射区域中未降低。我们的结果表明，帕金森病中退化的多巴胺能神经元的主要部分可能不含有CCK-8肽。
