Tenovuo O, Rinne U K, Viljanen M K
Brain Res. 1984 Jun 11;303(1):113-6. doi: 10.1016/0006-8993(84)90217-8.
The amount of substance P immunoreactivity (SPI) was measured by radioimmunoassay from the cerebral cortex, caudate nucleus, putamen, pallidum, substantia nigra, hypothalamus, nucleus accumbens, amygdala and hippocampus from autopsy brains. The whole material consisted of 42 parkinsonian patients and 31 controls. The amount of SPI was significantly decreased in the substantia nigra of the parkinsonian brain. There was also a significant decrease of SPI in the putamen of those parkinsonian patients, who had not received levoDOPA treatment. The levels of SPI in the other brain regions studied did not show any difference between parkinsonian patients and controls. The results obtained suggest that substance P (SP) may have a role in the pathophysiology of Parkinson's disease.
通过放射免疫分析法，对尸检大脑的大脑皮质、尾状核、壳核、苍白球、黑质、下丘脑、伏隔核、杏仁核和海马体中的P物质免疫反应性（SPI）进行了测量。整个样本包括42名帕金森病患者和31名对照者。帕金森病大脑的黑质中SPI的量显著降低。未接受左旋多巴治疗的帕金森病患者的壳核中SPI也显著降低。在研究的其他脑区中，帕金森病患者和对照者之间的SPI水平没有显示出任何差异。所得结果表明，P物质（SP）可能在帕金森病的病理生理学中起作用。
