• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

几种物种及精神分裂症患者中脑腹侧多巴胺能细胞中胆囊收缩素表达的分析。

Analysis of expression of cholecystokinin in dopamine cells in the ventral mesencephalon of several species and in humans with schizophrenia.

作者信息

Schalling M, Friberg K, Seroogy K, Riederer P, Bird E, Schiffmann S N, Mailleux P, Vanderhaeghen J J, Kuga S, Goldstein M

机构信息

Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.

出版信息

Proc Natl Acad Sci U S A. 1990 Nov;87(21):8427-31. doi: 10.1073/pnas.87.21.8427.

DOI:10.1073/pnas.87.21.8427
PMID:1978324
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC54969/
Abstract

The ventral mesencephalons of hamster, guinea pig, cat, monkey, and several humans with and without the diagnosis of schizophrenia were analyzed with in situ hybridization and immunohistochemistry. Extensive codistribution of cholecystokinin mRNA and tyrosine hydroxylase [L-tyrosine, tetrahydropteridine: oxygen oxidoreductase (3-hydroxylating), EC 1.14.16.2] mRNA was observed in cats and monkeys as well as in all five human subjects with the diagnosis of schizophrenia and in two out of five control brains. Double labeling revealed coexistence of the two markers in cat, monkey, and human. No cholecystokinin mRNA or cholecystokinin peptide was detected in the substantia nigra/ventral tegmental area of the hamster or guinea pig, even after acute and chronic neuroleptic treatment.

摘要

采用原位杂交和免疫组化方法，对仓鼠、豚鼠、猫、猴以及数名诊断为精神分裂症和未诊断为精神分裂症的人类的腹侧中脑进行了分析。在猫和猴以及所有五名诊断为精神分裂症的人类受试者和五名对照大脑中的两名中，观察到胆囊收缩素mRNA和酪氨酸羟化酶[L-酪氨酸，四氢生物蝶呤：氧氧化还原酶（3-羟化），EC 1.14.16.2]mRNA广泛共分布。双重标记显示这两种标记物在猫、猴和人类中共存。即使经过急性和慢性抗精神病药物治疗，在仓鼠或豚鼠的黑质/腹侧被盖区也未检测到胆囊收缩素mRNA或胆囊收缩素肽。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/fd771aa78db9/pnas01046-0253-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/c7ea583a6d13/pnas01046-0251-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/68fb372eb933/pnas01046-0251-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/c04c99ab4357/pnas01046-0251-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/ec7e4fd4dff0/pnas01046-0251-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/35e5be7b9005/pnas01046-0251-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/e1ab77ee01d5/pnas01046-0251-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/2827ff0ba2d0/pnas01046-0251-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/55388474475e/pnas01046-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/91d4ae24e6ee/pnas01046-0252-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/9bf048661f55/pnas01046-0252-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/ec93227a9572/pnas01046-0252-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/1f0ae357f9a0/pnas01046-0252-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/456407cd5b3d/pnas01046-0252-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/9ef1e88daa8a/pnas01046-0252-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/be49f3e2a155/pnas01046-0252-h.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/351fc2eb26e5/pnas01046-0252-i.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/b915895a5da5/pnas01046-0252-j.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/50a83fa1cfad/pnas01046-0252-k.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/1813531b36c6/pnas01046-0252-l.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/7eaca0e34ae8/pnas01046-0253-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/cae347f41f48/pnas01046-0253-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/cc8cf76e7449/pnas01046-0253-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/662060b3fac7/pnas01046-0253-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/58eedc10fc38/pnas01046-0253-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/fd771aa78db9/pnas01046-0253-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/c7ea583a6d13/pnas01046-0251-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/68fb372eb933/pnas01046-0251-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/c04c99ab4357/pnas01046-0251-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/ec7e4fd4dff0/pnas01046-0251-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/35e5be7b9005/pnas01046-0251-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/e1ab77ee01d5/pnas01046-0251-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/2827ff0ba2d0/pnas01046-0251-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/55388474475e/pnas01046-0252-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/91d4ae24e6ee/pnas01046-0252-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/9bf048661f55/pnas01046-0252-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/ec93227a9572/pnas01046-0252-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/1f0ae357f9a0/pnas01046-0252-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/456407cd5b3d/pnas01046-0252-f.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/9ef1e88daa8a/pnas01046-0252-g.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/be49f3e2a155/pnas01046-0252-h.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/351fc2eb26e5/pnas01046-0252-i.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/b915895a5da5/pnas01046-0252-j.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/50a83fa1cfad/pnas01046-0252-k.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/1813531b36c6/pnas01046-0252-l.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/7eaca0e34ae8/pnas01046-0253-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/cae347f41f48/pnas01046-0253-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/cc8cf76e7449/pnas01046-0253-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/662060b3fac7/pnas01046-0253-d.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/58eedc10fc38/pnas01046-0253-e.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09c7/54969/fd771aa78db9/pnas01046-0253-f.jpg

相似文献

1
Analysis of expression of cholecystokinin in dopamine cells in the ventral mesencephalon of several species and in humans with schizophrenia.几种物种及精神分裂症患者中脑腹侧多巴胺能细胞中胆囊收缩素表达的分析。
Proc Natl Acad Sci U S A. 1990 Nov;87(21):8427-31. doi: 10.1073/pnas.87.21.8427.
2
Cholecystokinin and tyrosine hydroxylase messenger RNAs in neurons of rat mesencephalon: peptide/monoamine coexistence studies using in situ hybridization combined with immunocytochemistry.大鼠中脑神经元中的胆囊收缩素和酪氨酸羟化酶信使核糖核酸：采用原位杂交与免疫细胞化学相结合的肽/单胺共存研究
Exp Brain Res. 1989;74(1):149-62. doi: 10.1007/BF00248288.
3
Cellular localization of tyrosine hydroxylase mRNA and cholecystokinin mRNA-containing cells in the ventral mesencephalon of the common marmoset: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.普通狨猴腹侧中脑中酪氨酸羟化酶mRNA和含胆囊收缩素mRNA细胞的细胞定位：1-甲基-4-苯基-1,2,3,6-四氢吡啶的作用
Brain Res Mol Brain Res. 1992 Jan;12(1-3):267-74. doi: 10.1016/0169-328x(92)90093-q.
4
Tyrosine hydroxylase and cholecystokinin mRNA levels in the substantia nigra, ventral tegmental area, and locus ceruleus are unaffected by acute and chronic haloperidol administration.急性和慢性给予氟哌啶醇对黑质、腹侧被盖区及蓝斑中酪氨酸羟化酶和胆囊收缩素的信使核糖核酸水平无影响。
Cell Mol Neurobiol. 1990 Mar;10(1):41-50. doi: 10.1007/BF00733634.
5
The colocalization of cholecystokinin and tyrosine hydroxylase mRNAs in mesencephalic dopaminergic neurons in the rat brain examined by in situ hybridization.采用原位杂交法检测大鼠脑中脑多巴胺能神经元中胆囊收缩素和酪氨酸羟化酶mRNA的共定位。
Neuroscience. 1989;29(2):363-9. doi: 10.1016/0306-4522(89)90063-8.
6
Ventral mesencephalic neurons containing both cholecystokinin- and tyrosine hydroxylase-like immunoreactivities project to forebrain regions.含有胆囊收缩素样和酪氨酸羟化酶样免疫反应性的腹侧中脑神经元投射到前脑区域。
J Comp Neurol. 1989 Jan 15;279(3):397-414. doi: 10.1002/cne.902790306.
7
Dopaminergic neurons in rat ventral midbrain express brain-derived neurotrophic factor and neurotrophin-3 mRNAs.大鼠腹侧中脑的多巴胺能神经元表达脑源性神经营养因子和神经营养素-3信使核糖核酸。
J Comp Neurol. 1994 Apr 15;342(3):321-34. doi: 10.1002/cne.903420302.
8
Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and human.酸性和碱性成纤维细胞生长因子在大鼠、猴及人类黑质中的表达。
Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10237-41. doi: 10.1073/pnas.88.22.10237.
9
Ontogeny of tyrosine hydroxylase and cholecystokinin gene expression in the rat mesencephalon.大鼠中脑酪氨酸羟化酶和胆囊收缩素基因表达的个体发生
Brain Res Dev Brain Res. 1990 Mar 1;52(1-2):85-93. doi: 10.1016/0165-3806(90)90224-m.
10
Tyrosine hydroxylase and dopamine transporter expression in residual dopaminergic neurons: potential contributors to spontaneous recovery from experimental Parkinsonism.酪氨酸羟化酶和多巴胺转运体在残余多巴胺能神经元中的表达：实验性帕金森病自发恢复的潜在因素。
J Neurosci Res. 2001 Aug 1;65(3):254-66. doi: 10.1002/jnr.1149.

引用本文的文献

1
Neuropeptide Cholecystokinin: A Potential Molecular Link Between Obesity, Gut, and Emotion.神经肽胆囊收缩素：肥胖、肠道与情绪之间潜在的分子纽带
Biol Psychiatry Glob Open Sci. 2023 Oct 16;3(4):582-584. doi: 10.1016/j.bpsgos.2023.08.010. eCollection 2023 Oct.
2
Somatodendritic Release of Cholecystokinin Potentiates GABAergic Synapses Onto Ventral Tegmental Area Dopamine Cells.胆囊收缩素在腹侧被盖区多巴胺细胞上增强 GABA 能突触传递的体树突释放。
Biol Psychiatry. 2023 Jan 15;93(2):197-208. doi: 10.1016/j.biopsych.2022.06.011. Epub 2022 Jun 22.
3
Cholecystokinin-Mediated Neuromodulation of Anxiety and Schizophrenia: A "Dimmer-Switch" Hypothesis.

本文引用的文献

1
[Distribution of noradrenaline and dopamine (3-hydroxytyramine) in the human brain and their behavior in diseases of the extrapyramidal system].[去甲肾上腺素和多巴胺（3-羟酪胺）在人脑内的分布及其在锥体外系疾病中的表现]
Klin Wochenschr. 1960 Dec 15;38:1236-9. doi: 10.1007/BF01485901.
2
Fluorescent antibody methods.荧光抗体法
Gen Cytochem Methods. 1958;1:399-422.
3
A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: evidence from immunohistochemistry combined with retrograde tracing.
胆囊收缩素介导的焦虑和精神分裂症的神经调节：“调光开关”假说。
Curr Neuropharmacol. 2021;19(7):925-938. doi: 10.2174/1570159X18666201113145143.
4
Understanding opioid reward.理解阿片类药物奖赏机制。
Trends Neurosci. 2015 Apr;38(4):217-25. doi: 10.1016/j.tins.2015.01.002. Epub 2015 Jan 29.
5
Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.通过基质细胞衍生的诱导活性从灵长类胚胎干细胞生成多巴胺能神经元和色素上皮细胞。
Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1580-5. doi: 10.1073/pnas.032662199. Epub 2002 Jan 29.
6
Inhibitory activity of the equine infectious anemia virus major 5' splice site in the absence of Rev.马传染性贫血病毒主要5'剪接位点在缺乏Rev情况下的抑制活性
J Virol. 1996 Jun;70(6):3645-58. doi: 10.1128/JVI.70.6.3645-3658.1996.
7
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis.小鼠β-珠蛋白DNA结合蛋白B1与一种原癌基因即转录因子Spi-1/PU.1相同，并且其表达仅限于造血细胞和睾丸。
Mol Cell Biol. 1993 May;13(5):2929-41. doi: 10.1128/mcb.13.5.2929-2941.1993.
投射至边缘区域的中脑多巴胺能神经元亚群含有一种胆囊收缩素样肽：免疫组织化学与逆行追踪相结合的证据
Neuroscience. 1980;5(12):2093-124. doi: 10.1016/0306-4522(80)90127-x.
4
Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat.
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1190-4. doi: 10.1073/pnas.77.2.1190.
5
CCK-8-Immunoreactivity distribution in human brain: selective decrease in the substantia nigra from parkinsonian patients.胆囊收缩素-8在人脑中的免疫反应性分布：帕金森病患者黑质中的选择性减少。
Brain Res. 1982 Jul 8;243(1):176-9. doi: 10.1016/0006-8993(82)91135-0.
6
Analgesia and ptosis caused by caerulein and cholecystokinin octapeptide (CCK-8).蛙皮素和胆囊收缩素八肽（CCK-8）引起的镇痛和上睑下垂。
Neuropharmacology. 1980 May;19(5):415-22. doi: 10.1016/0028-3908(80)90047-7.
7
Cloning and sequence analysis of a cDNA encoding rat preprocholecystokinin.大鼠前胆囊收缩素原cDNA的克隆与序列分析
Proc Natl Acad Sci U S A. 1984 Feb;81(3):726-30. doi: 10.1073/pnas.81.3.726.
8
In rats, the behavioral profile of CCK-8 related peptides resembles that of antipsychotic agents.在大鼠中，CCK - 8相关肽的行为特征与抗精神病药物相似。
Eur J Pharmacol. 1983 Sep 16;93(1-2):63-78. doi: 10.1016/0014-2999(83)90031-6.
9
Cholecystokinin-octapeptide effects on conditioned-avoidance behavior, stereotypy and catalepsy.胆囊收缩素八肽对条件性回避行为、刻板行为和僵住症的影响。
Eur J Pharmacol. 1982 Sep 24;83(3-4):213-22. doi: 10.1016/0014-2999(82)90254-0.
10
Evidence for coexistence of dopamine and CCK in meso-limbic neurones.中脑边缘神经元中多巴胺与胆囊收缩素共存的证据。
Nature. 1980 Jun 12;285(5765):476-8. doi: 10.1038/285476a0.