在脂蛋白存在的情况下，人脂肪细胞中新合成的角鲨烯、甲基甾醇和胆固醇的释放。

Release of newly synthesized squalene, methyl sterols and cholesterol from human adipocytes in the presence of lipoproteins.

作者信息

Tilvis R S, Kovanen P T, Miettinen T A

出版信息

Scand J Clin Lab Invest. 1978 Feb;38(1):83-7. doi: 10.3109/00365517809108407.

Abstract

Upon incubation of free fat cells for 3 h with labelled mevalonate, more than 90% of the radioactivity of the non-saponifiable material was found in the squalene fraction and less than 10% in the methyl sterol and cholesterol fractions. About 25, 30 and 65% of the cholesterol counts were found respectively in VLDL, LDL, or HDL added to the medium while none of the newly synthesized squalene was released into the lipoproteins. The results indicate that adipose tissue squalene can originate from local synthesis. It is not released from the cells into the medium, but can contribute to local cholesterol synthesis in both rapidly and slowly exchangeable cholesterol pools of adipose tissue.

摘要

将游离脂肪细胞与标记的甲羟戊酸一起孵育3小时后，发现非皂化物质中90%以上的放射性存在于角鲨烯部分，而甲基甾醇和胆固醇部分中的放射性不到10%。在添加到培养基中的极低密度脂蛋白（VLDL）、低密度脂蛋白（LDL）或高密度脂蛋白（HDL）中分别发现约25%、30%和65%的胆固醇计数，而新合成的角鲨烯没有释放到脂蛋白中。结果表明，脂肪组织中的角鲨烯可能源自局部合成。它不会从细胞释放到培养基中，但可有助于脂肪组织快速和缓慢交换的胆固醇池中局部胆固醇的合成。