Nagao K, Matsuzaki O, Saiga H, Sugano I, Shigematsu H, Kaneko T, Katoh T, Kitamura T
Cancer. 1982 Oct 15;50(8):1572-9. doi: 10.1002/1097-0142(19821015)50:8<1572::aid-cncr2820500818>3.0.co;2-l.
Five-hundred-fifty-five primary epithelial tumors of parotid gland origin were examined. Eighteen cases could be defined undifferentiated carcinomas, constituting 3.2% of the total number or 10.2% of 176 malignant tumors. The undifferentiated carcinomas could be divided on the basis of the cell size into two types: (1) Small-cell type (12/18; 66.7%); the tumor cells were as large as, or slightly larger than lymphocytes. The cytoplasm was scanty with dark chromatin. Mitotic figures were numerous. The tumor cells in the periphery of the cell clusters exhibited a palisading arrangement. Electron microscopy revealed that these cells were rich in tonofilaments and connected by desmosomes. (2) Large-cell type (6/18; 33.3%); the carcinoma cells were roughly twice as large as those of the small-cell carcinoma. The tumor cells were spheroidal or spindle in shape with rich and clear cytoplasm. Many of the tumor-cell clusters showed macroalveolar structures, suggesting the possibility that this type occurred as a variant of poorly differentiated adenocarcinoma or epidermoid carcinoma. Clinicopathologically, there was no sex difference in the total number of the undifferentiated carcinomas, but the large-cell carcinomas were frequently encountered in females (83.3%). As to the age distribution, the carcinomas were found frequently in middle-aged patients from 30-49 years (66.7%). Many of the tumors were 2-4.9 cm at their greatest diameter (55.6%). Tumor mass less than 1.9 cm could not be found.
对555例腮腺原发性上皮性肿瘤进行了检查。18例可诊断为未分化癌，占总数的3.2%，占176例恶性肿瘤的10.2%。未分化癌可根据细胞大小分为两型：（1）小细胞型（12/18；66.7%）；肿瘤细胞与淋巴细胞大小相同或略大。细胞质稀少，染色质深。有丝分裂象众多。细胞团周边的肿瘤细胞呈栅栏状排列。电镜显示这些细胞富含张力丝并通过桥粒相连。（2）大细胞型（6/18；33.3%）；癌细胞大小约为小细胞癌的两倍。肿瘤细胞呈球形或梭形，细胞质丰富且清晰。许多肿瘤细胞团显示出大肺泡结构，提示该型可能是低分化腺癌或表皮样癌的一种变异。临床病理方面，未分化癌总数无性别差异，但大细胞癌多见于女性（83.3%）。在年龄分布上，癌多见于30 - 49岁的中年患者（66.7%）。许多肿瘤最大直径为2 - 4.9 cm（55.6%）。未发现直径小于1.9 cm的肿瘤块。
