Donath K, Seifert G, Lentrodt J
Virchows Arch A Pathol Anat Histopathol. 1984;403(4):425-40. doi: 10.1007/BF00737291.
Embryonal tumors are a neoplastic proliferation of cells of organ rudiments. Morphologically, these tumors are similar to the developmental stages of these organ rudiments. Embryonal tumors of the salivary glands have not been previously described. In the salivary gland register, reviewing the years 1965-1982 (n = 8043), we diagnosed 2,878 tumors of the salivary glands, of these 73 were tumors in children. One case was a malignant epithelial tumor in a 12-year-old boy, which showed the criteria of an embryonal carcinoma in light- and electron microscopy. The tumor revealed solid undifferentiated areas, epidermoid structures with keratinization and acinic structures. Immunhistochemically, the better differentiated epidermoid cells reacted positively with anti-CEA and anti-keratin, the acinic cells were positive with anti-amylase. The ultrastructure was characterized by primitive ductular epithelial cells and acinic cells with their typical morphological features. The embryonal carcinoma has to be distinguished from undifferentiated carcinomas of the salivary glands, which consist of primitive ductular structures only. The failure to detect other tumor markers (lactoferrin, tissue polypeptid antigen) indicates that poorly and well differentiated areas can exist simultaneously in embryonal carcinomas.
胚胎性肿瘤是器官原基细胞的肿瘤性增殖。从形态学上看，这些肿瘤类似于这些器官原基的发育阶段。涎腺胚胎性肿瘤此前尚未见报道。在涎腺登记处，回顾1965年至1982年（n = 8043）期间，我们诊断出2878例涎腺肿瘤，其中73例为儿童肿瘤。1例为12岁男孩的恶性上皮性肿瘤，光镜和电镜检查显示符合胚胎癌的标准。肿瘤表现为实性未分化区域、有角化的表皮样结构和腺泡样结构。免疫组化显示，分化较好的表皮样细胞与抗癌胚抗原和抗角蛋白呈阳性反应，腺泡样细胞与抗淀粉酶呈阳性反应。超微结构的特征是原始导管上皮细胞和具有典型形态特征的腺泡样细胞。胚胎癌必须与仅由原始导管结构组成的涎腺未分化癌相鉴别。未能检测到其他肿瘤标志物（乳铁蛋白、组织多肽抗原）表明胚胎癌中可能同时存在分化差和分化好的区域。
