Helwig H, Daschner F
Dtsch Med Wochenschr. 1982 Sep 10;107(36):1343-6. doi: 10.1055/s-2008-1070126.
Cefotaxim was administered to ten children with purulent meningitis. All isolated micro-organisms were highly sensitive to it in serial dilution, except for one case, and were quickly removed from blood and CSF by the administration of cefotaxim alone. Blood and CSF concentrations measured in eight children were much above the minimal inhibitory concentration for the particular micro-organism. Thus cefotaxim has a high antibacterial activity and satisfactory CSF passage in purulent meningitis caused by sensitive, especially gram-negative, bacteria and is well suitable for therapy, if penicillins alone or combined are not applicable or effective.
对10名患有化脓性脑膜炎的儿童使用了头孢噻肟。除1例病例外，所有分离出的微生物在系列稀释中对其高度敏感，并且仅通过给予头孢噻肟就迅速从血液和脑脊液中清除。在8名儿童中测得的血液和脑脊液浓度远高于特定微生物的最低抑菌浓度。因此，头孢噻肟在由敏感菌，尤其是革兰氏阴性菌引起的化脓性脑膜炎中具有高抗菌活性和令人满意的脑脊液透过性，并且如果单独使用青霉素或联合使用青霉素不适用或无效时，它非常适合用于治疗。
