垂体门脉血中促肾上腺皮质激素释放因子样免疫反应性的存在。
Presence of corticotropin releasing factor-like immunoreactivity in hypophysial portal blood.
作者信息
Gibbs D M, Vale W
出版信息
Endocrinology. 1982 Oct;111(4):1418-20. doi: 10.1210/endo-111-4-1418.
Hypophysial protal blood was collected from pentobarbital anesthetized male rats, and the content of corticotropin releasing factor-like immunoreactivity (CRF-LI) was measured using an RIA developed for synthetic ovine CRF. The concentration of CRF-LI in portal plasma was 104.9 +/- 9.7 pM. This concentration is in the range which has been shown to stimulate ACTH and beta-endorphin secretion in vitro. These data support the hypothesis that a molecule with the same or similar structure as synthetic ovine CRF is a physiologically significant hypothalamic releasing factor.
从戊巴比妥麻醉的雄性大鼠采集垂体门脉血，使用针对合成羊促肾上腺皮质激素释放因子（CRF）开发的放射免疫分析法（RIA）测量促肾上腺皮质激素释放因子样免疫反应性（CRF-LI）的含量。门脉血浆中CRF-LI的浓度为104.9±9.7皮摩尔。该浓度处于已证明能在体外刺激促肾上腺皮质激素（ACTH）和β-内啡肽分泌的范围内。这些数据支持这样的假设，即具有与合成羊CRF相同或相似结构的分子是一种具有生理意义的下丘脑释放因子。
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