Gibbs D M, Stewart R D, Vale W, Rivier J, Yen S S
Life Sci. 1983 Jan 31;32(5):547-50. doi: 10.1016/0024-3205(83)90150-9.
Synthetic ovine CRF, in an amount approximating that found in pituitary portal plasma of the rat, induced a significant increase in the secretion of both ACTH and immunoreactive beta-endorphin/beta-LPH (i beta-END/LPH) by human fetal hemipituitaries in an in vitro superfusion system. This finding suggests that a molecule similar to synthetic ovine CRF may be a physiologic hypothalamic releasing factor in man.
合成羊促肾上腺皮质激素释放因子（CRF），其含量接近大鼠垂体门脉血浆中的含量，在体外灌注系统中可使人类胎儿半垂体促肾上腺皮质激素（ACTH）和免疫反应性β-内啡肽/β-促脂解素（iβ-END/LPH）的分泌显著增加。这一发现表明，一种类似于合成羊CRF的分子可能是人类生理性下丘脑释放因子。
