Grundy J E, Melief C J
J Gen Virol. 1982 Jul;61 (Pt l):133-6. doi: 10.1099/0022-1317-61-1-133.
Adult athymic Nu/Nu mice showed increased susceptibility to lethal infection with murine cytomegalovirus (MCMV) when compared to their heterozygous T cell-competent Nu/+ littermates. However, the extent of this increase in susceptibility varied dramatically depending on the genetic background of the mice carrying the Nu/Nu gene. Genetically susceptible Balb/c (H-2d) mice showed a greater than 316-fold difference between the LD50 of Nu/Nu and Nu/+ littermates. In marked contrast, the genetically resistant CBA (H-2K) strain was characterized by only a 16-fold difference in resistance between Nu/Nu and Nu/+ mice, and furthermore, the athymic CBA Nu/Nu mice were no susceptible than the T cell-competent Balb/c Nu/+ strain. These results together with previous observations strongly suggest that the (H-2k)-associated resistance of the CBA strain is mediated by non-T cell-dependent early defence mechanisms.
与具有T细胞功能的杂合子Nu/+同窝小鼠相比，成年无胸腺Nu/Nu小鼠对鼠巨细胞病毒（MCMV）致死性感染的易感性增加。然而，这种易感性增加的程度因携带Nu/Nu基因小鼠的遗传背景不同而有很大差异。遗传易感的Balb/c（H-2d）小鼠中，Nu/Nu和Nu/+同窝小鼠的半数致死剂量（LD50）相差超过316倍。与之形成鲜明对比的是，遗传抗性的CBA（H-2K）品系中，Nu/Nu和Nu/+小鼠之间的抗性差异仅为16倍，此外，无胸腺的CBA Nu/Nu小鼠并不比具有T细胞功能的Balb/c Nu/+品系更易感。这些结果与之前的观察结果共同强烈表明，CBA品系的（H-2k）相关抗性是由非T细胞依赖性早期防御机制介导的。
