对防火剂FF-1中多溴联苯的角化过度活性的研究。

Investigation of hyperkeratotic activity of polybrominated biphenyls in Firemaster FF-1.

作者信息

Needham L L, Hill R H, Orti D L, Patterson D G, Kimbrough R D, Groce D F, Liddle J A

出版信息

J Toxicol Environ Health. 1982 May-Jun;9(5-6):877-87. doi: 10.1080/15287398209530210.

DOI:10.1080/15287398209530210

Abstract

A polybrominated biphenyl (PBB) mixture was fractionated by normal-phase preparative high-performance liquid chromatography. The hexane fractions were concentrated and applied to rabbit ears. Only the most polar fraction produced hyperkeratosis on the rabbit ears. This active fraction was subfractionated by using the same procedure. Again, the extent of hyperkeratotic activity increased with increasing polarity. The PBBs of the largest concentration levels in the active fraction were purified by preparative gas chromatography and tested on rabbit ears. The major compounds did not demonstrate hyperkeratotic activity.

摘要

通过正相制备高效液相色谱法对多溴联苯（PBB）混合物进行分馏。将己烷馏分浓缩并涂抹于兔耳。只有极性最强的馏分在兔耳上产生了角化过度。使用相同程序对该活性馏分进行再分馏。同样，角化过度活性的程度随极性增加而增强。通过制备气相色谱法对活性馏分中浓度最高的多溴联苯进行纯化，并在兔耳上进行测试。主要化合物未表现出角化过度活性。